The intravascular survival of transfused canine Pelger-Huet neutrophils and eosinophils.

T HE PELGER-HU1 T ( P-H ) anomaly of leukocytes is a benign, dominant hereditary trait which primarily affects the granulocytic leukocytes. Poor segmentation and abnormal condensation of nuclear chromatin are characteristic of this anomaly, which has been described in humans,1’2 rabbits3 and more recently in the dog.4 Klein et al.5 have extensively reviewed the literature prior to 1955. Skendzel and Hoffman#{176} have recently reviewed 41 human cases of the anomaly. Rosse and Gurney7 used Pelger-Huet cells to demonstrate the intravascular survival of transfused neutrophils. Recent studies8 of neutrophils labeled with diisopropylfluorophosphate ( DFP32) have confirmed Rosse and Gurney’s earlier estimate of 6 to 8 hours half-time ( Tl/2). This paper will report the intravascular survival of transfused canine PelgerHu#{235}t neutrophils and eosinophils.